It’s a fun and genuinely interesting talk, certainly worthwhile reading/watching. The links are above.
The New York Times article reminded me of the lecture, also it announces Dr. Pausch’s book. If it is anywhere as moving as his lecture, it is likely to be a worthwhile read. I have it on order and encourage others to do so.
If you’re having a tough day and want to get your head above the weeds, take the time to read/watch the lecture. It helps clear your mind and put things in proper perspective.